Title
Topic
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‘Biochemical Characterization of Disease-Associated Variants of Human Ornithine Transcarbamylase’
“Human ornithine transcarbamylase deficiency (OTCD) is the most common ureagenesis disorder in the world. OTCD is an X-linked genetic deficiency in which patients experience hyperammonemia to varying degrees depending on the severity of the genetic mutation. More than two-thirds of the known mutations are caused by single nucleotide substitutions. In this paper, partial order optimum likelihood (POOL), a machine learning method, is used to analyze single nucleotide substitutions in OTC with varying disease phenotypes and predicted catalytic efficiencies.” Find the paper and full list of authors in ACS Chemical Biology.
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‘The Microbiome’s Influence on the Neurobiology of Opioid Addiction and Brain Connectivity’
“Opioids are the most effective and potent analgesics available for acute pain management. With no viable alternative for treating chronic or post operative pain, it is not surprising that over 10 million people misuse opioids. This study explores the developmental influence of the microbiome on resistance to opioid addictive behavior and functional connectivity.” Find the paper and full list of authors in Brain Research Bulletin.
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‘Site-Specific Growth and Printing of Nanowires for Resource Efficient Fabrication of Flexible Electronics’
“Semiconducting nanowires (NWs) hold great potential for high-performance flexible electronics. However, using them, to fabricate electronic devices, is a complex process requiring multiple lithography steps to address the issues such as the one arising from mismatches between the temperatures needed for NW growth and the temperatures the polymeric substrates can withstand. Herein, a facile “design to fab” approach is presented, which avoids lithography-based fabrication by implementing the device layout at the NW synthesis level itself.” Find the paper and full list of authors in Small.
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‘Antibiotic Pretreatment Inhibits White Band Disease Infection by Suppressing the Bacterial Pathobiome’
“Diseases have caused unprecedent mortality in Caribbean coral communities. White band disease (WBD) has killed up to 95% of all endangered Caribbean Acroporids since it was first observed in 1979. … To better understand the disease etiology of WBD, we pretreated corals with antibiotics to determine how prophylactic use of antibiotics impacts the transmission of WBD in a replicated tank-based experiment. We found the prophylactic use of antibiotics led to significantly reduced infection rates in disease exposed corals with a 30-percentage point decrease in the infection rate.” Find the paper and full list of authors in Frontiers in Marine Science.
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Patent combines drugs with immunotherapy for cancer treatment
“Bouvé/chemical engineering University Distinguished Professor Mansoor Amiji was awarded a patent for ‘Combination Taxoid Nanoemulsion With Immunotherapy in Cancer.'”
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System for closed-loop GNSS
“Electrical and computer engineering associate professor Pau Closas was awarded a patent for ‘System for Closed-Loop GNSS Simulation.'”
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‘Integrating AI into the Front End of New Product Development’
“This study explores the integration of artificial intelligence (AI) into the fuzzy front end (FFE) of new product development (NPD). Using the AI-augmented LUCID platform, we demonstrate how large-scale customer data can be synthesized to enhance decision-making, accelerate concept development, and improve product evaluation efficiency. While traditional NPD methods are time-intensive and rely heavily on subjective expertise, AI streamlines the process by generating and evaluating thousands of design options in real time. Our findings show that AI augments human expertise by identifying critical insights within vast datasets, uncovering previously overlooked opportunities.” Find the paper and authors list in Research-Technology Management.
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‘AI’s Hidden Human Cost, and How To Avoid It’
“AI adoption offers immense opportunities but poses significant challenges at the same time, particularly when organisations prioritise automation and efficiency over human augmentation. While AI can boost efficiency, it also risks increasing workloads, causing burnout, and diminishing interpersonal skills.”
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‘Root of Unity Quantum Cluster Algebras and Discriminants’
“We describe a connection between the subjects of cluster algebras, polynomial identity algebras, and discriminants. For this, we define the notion of root of unity quantum cluster algebras and prove that they are polynomial identity algebras. Inside each such algebra we construct a (large) canonical central subalgebra, which can be viewed as a far reaching generalization of the central subalgebras of big quantum groups constructed by De Concini, Kac, and Procesi and used in representation theory.” Find the paper and full list of authors in Journal of the London Mathematical Society.
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‘Getting out of South Carolina’s Juvenile Justice System’
Incarcerated juveniles in South Carolina often “receive fewer hours of education than they were getting prior to incarceration, if any. Getting out of South Carolina’s Juvenile Justice System highlights the importance of prevention and community programming, as well as preparation for the return to mainstream society. Through stories from juveniles, parents, judges, prosecutors and defense attorneys, author Kimberly Nolan addresses the issues within the juvenile justice system in South Carolina and offers ideas on how to support young offenders as they navigate both the transition to adulthood and community living.”
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Abowd receives ACM SIGCHI Special Recognition Award
“Gregory D. Abowd, dean of the College of Engineering and professor of electrical and computer engineering, received the Association of Computing Machinery Special Interest Group on Computer-Human Interaction (ACM SIGCHI) Special Recognition Award ‘for his extraordinary ability to inspire and mentor individuals from diverse backgrounds and his commitment to fostering collaboration, creativity, and impact.’ … Awardees’ achievements will be celebrated at the ACM CHI 2025 conference in Yokohama, Japan in April 2025.”
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‘Network Coding for Engineers’
According to the publisher’s webpage, “‘Network Coding for Engineers’ introduces the fundamentals of this exciting subject from an engineering perspective. Beginning with the basics, including step-by-step details for implementing network coding and current applications, it also highlights potential uses of network coding in the communications technologies of the future. The result is an innovative and accessible introduction to a subject quickly becoming indispensable.” Find the full list of authors at Wiley.
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Stevenson selected to receive Young Investigator Award
Assistant professor of physics Paul Stevenson has been selected to receive an Air Force Office of Scientific Research Young Investigator Award “for a new project using quantum sensors to explore electron transport in biomolecules.”
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‘Responses of Littorina spp. Intertidal Snails to Thermal Extremes Indicate Countergradient Variation in Fitness’
“Global change models predict not only a steady increase in temperatures but also an increase in the occurrence of hot and cold extremes. Organisms’ responses to thermal extremes will depend on species-specific traits and the degree of within-species variation (among populations). … The evolution of population-specific responses, however, can be limited by gene flow that homogenises populations. Here, we investigate this relationship with a study of the survival of Littorina littorea, L. obtusata, and L. saxatilis—marine snails with varying dispersal potential—collected on either side of a known biogeographic break.” Find the paper and list of authors in Ecology and Evolution.
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‘A Phosphorylation Signal Activates Genome-Wide Transcriptional Control by BfmR’
“The nosocomial pathogen Acinetobacter baumannii is a major threat to human health. The sensor kinase-response regulator system, BfmS-BfmR, is essential to multidrug resistance and virulence in the bacterium and represents a potential antimicrobial target. Important questions remain about how the system controls resistance and pathogenesis. Although BfmR knockout alters expression of >1000 genes, its direct regulon is undefined. Moreover, how phosphorylation controls the regulator is unclear. Here, we address these problems by combining mutagenesis, ChIP-seq, and in vitro phosphorylation to study the functions of phospho-BfmR.” Find the paper and full list of authors in Nucleic Acids Research.
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‘A Prospective Real-Time Transfer Learning Approach To Estimate Influenza Hospitalizations With Limited Data’
“Accurate, real-time forecasts of influenza hospitalizations would facilitate prospective resource allocation and public health preparedness. State-of-the-art machine learning methods are a promising approach to produce such forecasts, but they require extensive historical data to be properly trained. Unfortunately, data on influenza hospitalizations, for the 50 states in the United States, are only available since the beginning of 2020. In addition, the data are far from perfect as they were under-reported for several months before health systems began consistently submitting their data. To address these issues, we propose a transfer learning approach.” Find the paper and list of authors in Epidemics.
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‘3D Spatial Distribution of Sost mRNA and Sclerostin Protein Expression in Response to In Vivo Tibia Loading in Female Mice’
“Bones adapt to external mechanical loads through a process known as mechanoadaptation. Osteocytes are the bone cells that sense the mechanical environment and initiate a biological response. Investigating the changes in osteocyte molecular expression following mechanical loading has been instrumental in characterizing the regulatory pathways involved in bone adaptation. … In this study, we used WISH-BONE (Whole-mount In Situ Histology of Bone) to investigate the spatial distribution of Sost-mRNA transcripts and its encoded protein, sclerostin, in 3D mouse tibia midshaft following in vivo tibia loading.” Find the paper and full list of authors in Bone.
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‘Human Mobility Is Well Described by Closed-Form Gravity-Like Models Learned Automatically From Data’
“Modeling human mobility is critical to address questions in urban planning, sustainability, public health, and economic development. … At one end of the modeling spectrum we have gravity models, which are easy to interpret but provide modestly accurate predictions of flows. At the other end, we have machine learning models, … which predict mobility more accurately than gravity models but do not provide clear insights on human behavior. Here, we show that simple machine-learned, closed-form models of mobility can predict mobility flows as accurately as complex machine learning models, and extrapolate better.” Find the paper and list of authors in…
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‘Practical Business Analytics Using R and Python’
From the publisher: “This book illustrates how data can be useful in solving business problems. It explores various analytics techniques for using data to discover hidden patterns and relationships, predict future outcomes, optimize efficiency and improve the performance of organizations. You’ll learn how to analyze data by applying concepts of statistics, probability theory, and linear algebra. In this new edition, both R and Python are used to demonstrate these analyses. Practical Business Analytics Using R and Python also features new chapters covering databases, SQL, Neural networks, Text Analytics, and Natural Language Processing.”
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‘Make Better Strategic Decisions Around Slow-Developing Technology’
“Self-driving automobiles may seem like a cutting-edge 21st-century technology — a challenge still facing obstacles before widespread adoption. But in fact, autonomous driving has been evolving in fits and starts for a full century. Its evolution can teach managers how to deal with innovations that depend on multiple slow-developing technologies that come together at different speeds and costs.” Find the paper and full list of authors in Harvard Business Review.
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Mosallaei made Optica Fellow
“Electrical and computer engineering professor Hossein Mosallaei was selected as a Fellow of Optica (formerly OSA) for outstanding contributions in active and time-modulated optical nanoantennas and metasurfaces. Optica Fellows are chosen based on several factors, including outstanding contributions to research, business, education, engineering, and service to Optica and its community.”
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‘A Hypothesis: Metabolic Contributions to 16p11.2 Deletion Syndrome’
“16p11.2 deletion syndrome is a severe genetic disorder associated with the deletion of 27 genes from a Copy Number Variant region on human chromosome 16. … We present a hypothesis in which changes in the dosage of 16p11.2 metabolic genes contribute to pathology through direct or indirect alterations in pathways that include amino acids or proteins, DNA, RNA, catabolism, lipid, energy (carbohydrate). This hypothesis suggests that research into the specific roles of each metabolic gene will help identify useful therapeutic targets.” Find the paper and full list of authors in BioEssays.
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‘Data Analytics Adoption, Social Support and Internal Auditor Performance’
“Data analytics are regarded as indispensable in enhancing auditor performance in the era of rapid technology advancements and Big Data. We examine the extent to which social support facilitates internal auditor adoption of data analytics, and whether the use of data analytics is associated with performance. … We document that peer social support developed through coparticipation in company trainings, accelerates the adoption of data analytics in various internal audit tasks including continuous auditing, communication, aligning risks and controls, and aligning data analytics with business control objectives.” Find the paper and full list of authors in Auditing.
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‘Model Supports Asymmetric Regulation Across the Intercellular Junction for Collective Cell Polarization’
“Symmetry breaking, which is ubiquitous in biological cells, functionally enables directed cell movement and organized embryogenesis. Prior to movement, cells break symmetry to form a well-defined cell front and rear in a process called polarization. In developing and regenerating tissues, collective cell movement requires the coordination of the polarity of the migration machineries of neighboring cells. … Here, we investigated how polarity signals are communicated from one cell to its neighbor to ensure coordinated front-to-rear symmetry breaking with the same orientation across the group.” Find the paper and full list of authors in Computational Biology.